WHOLE GENOME PROFILING OF SHORT-TERM HYPOXIA INDUCED GENES AND IDENTIFICATION OF HIF-1 BINDING SITES PROVIDE INSIGHTS INTO HIF-1 FUNCTION IN CAENORHABDITIS ELEGANS.

Oxygen is essential to all the aerobic organisms.However, blondor pale quartz during normal development, disease and homeostasis, organisms are often challenged by hypoxia (oxygen deprivation).Hypoxia-inducible transcription factors (HIFs) are master regulators of hypoxia response and are evolutionarily conserved in metazoans.The homolog of HIF in

The shear strength of prestressed beam elements is of great interest with regard to the evaluation of existing concrete bridges.Accompanying extensive experimental test series, the adaptation and modification of existing models for the evaluation of the load-bearing capacity also represents an important step.Against this background, considerations

Background and Objective: Pain is a common postoperative complaint, and the use of analgesics before surgical trauma can effectively prevent peripheral and central sensitization.We aimed to compare the preemptive effects of ibuprofen and celecoxib on post-operative pain after lower abdominal surgery in addicted patients.Materials and Methods: In th

Abstract Background Surveys of the public in a range of Western countries have shown a predominant belief in social stressors as causes of mental disorders.However, there has been little direct cross-cultural comparison.Here we report a comparison of public beliefs about the causes of mental disorders in Japan and Australia.Methods Surveys of the p

Vacuolar type rotary H+-ATPases (VoV1) couple ATP synthesis/hydrolysis by V1 with proton translocation by Vo via rotation of a central rotor apparatus composed of the V1-DF rotor shaft, a socket-like Vo-C (eukaryotic Vo-d) and the hydrophobic rotor ring.Reconstitution experiments using subcomplexes revealed a weak binding affinity of V1-DF to Vo-C